PROTO will develop novel interventional strategies aimed at tackling the development and progression of osteoarthritis (OA). The PROTO partners, from academic and industrial backgrounds are world-leading experts in OA research and treatment. They have demonstrable expertise in using omics platforms, cellular immunology, molecular biomarkers, physiology, biomechanics and stem cell biology and are actively involved in performing groundbreaking clinical studies, in particular also with advanced therapy medicinal products (ATMPs). Within PROTO we have joined forces to address the key feature of OA progression – inflammation.